A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters from chromone and isatin.
RSC Adv
; 9(63): 37057-37060, 2019 Nov 11.
Article
em En
| MEDLINE
| ID: mdl-35539051
ABSTRACT
A simple and convenient synthesis of 3-salicyloylquinoline-4-carboxylic esters has been developed through an AlCl3-catalyzed reaction of easily available Baylis-Hillman adducts from chromones and isatin-derivatives. This reaction involves esterification, cyclization and ring opening in a one-step process, and provides an efficient approach for easy access to a series of valuable salicyloylquinoline derivatives with high yields. Moreover, this protocol offers several advantages, such as availability of starting materials, economic availability, operational simplicity and mild reaction conditions.
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MEDLINE
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En
Ano de publicação:
2019
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Article