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Antiacetylcholinesterase triterpenes from the fruits of Cimicifuga yunnanensis.
Nian, Yin; Lu, Ni-Hong; Liu, Xiao-Ling; Li, Da-Shan; Zhou, Lin; Qiu, Ming-Hua.
Afiliação
  • Nian Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China mhchiu@mail.kib.ac.cn.
  • Lu NH; Department of Respiratory Medicine, The Third People's Hospital of Kunming Kunming 650041 People's Republic of China.
  • Liu XL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China mhchiu@mail.kib.ac.cn.
  • Li DS; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China mhchiu@mail.kib.ac.cn.
  • Zhou L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China mhchiu@mail.kib.ac.cn.
  • Qiu MH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming 650201 People's Republic of China mhchiu@mail.kib.ac.cn.
RSC Adv ; 8(14): 7832-7838, 2018 Feb 14.
Article em En | MEDLINE | ID: mdl-35539105
ABSTRACT
Two new cycloartane triterpenes, cimyunnin E (1), containing a unique oxaspiro[4.4]nonanedione moiety based on rings D and E, together with cimicifine B (2), a 25,26,27-trinortriterpene featuring a pyridine ring E, were purified from the fruits of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic methods and ECD (electronic circular dichroism calculations). Compounds 1 and 2 showed significant acetylcholinesterase (AChE) inhibition with IC50 values of 1.58 and 3.87 µM, respectively. In addition, they noticeably enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at a concentration of 10 µM.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article