Molecular characterization of chronic liver disease dynamics: From liver fibrosis to acute-on-chronic liver failure.

Graupera, Isabel; Isus, Laura; Coll, Mar; Pose, Elisa; Díaz, Alba; Vallverdú, Julia; Rubio-Tomás, Teresa; Martínez-Sánchez, Celia; Huelin, Patricia; Llopis, Marta; Solé, Cristina; Fondevila, Constantino; Lozano, Juan José; Sancho-Bru, Pau; Ginès, Pere; Aloy, Patrick

Graupera, Isabel; Isus, Laura; Coll, Mar; Pose, Elisa; Díaz, Alba; Vallverdú, Julia; Rubio-Tomás, Teresa; Martínez-Sánchez, Celia; Huelin, Patricia; Llopis, Marta; Solé, Cristina; Fondevila, Constantino; Lozano, Juan José; Sancho-Bru, Pau; Ginès, Pere; Aloy, Patrick.

Afiliação

Graupera I; Liver Unit, Hospital Clínic, Barcelona, Catalonia, Spain.
Isus L; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Coll M; Medicine department, Faculty of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.
Pose E; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Díaz A; Institute for Research in Biomedicine (IRB Barcelona) and The Barcelona Institute of Science and Technology. Barcelona, Catalonia, Spain.
Vallverdú J; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Rubio-Tomás T; Medicine department, Faculty of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.
Martínez-Sánchez C; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Huelin P; Liver Unit, Hospital Clínic, Barcelona, Catalonia, Spain.
Llopis M; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Solé C; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Catalonia, Spain.
Fondevila C; Pathology Service, Hospital Clinic-IDIBAPS, Barcelona, Spain.
Lozano JJ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Sancho-Bru P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Ginès P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
Aloy P; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

JHEP Rep ; 4(6): 100482, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35540106

Palavras-chave

ACLF; ACLF, acute-on-chronic liver failure; CC, compensated cirrhosis; CLD, chronic liver disease; CRP, C-reactive protein; DC, decompensated cirrhosis; DEGs, differentially expressed genes; GSEA, gene set-enrichment analyses; HCC, hepatocellular carcinoma; HSC, hepatic stellate cells; KRT-18, keratin-18; LDRN, liver disease-related protein-protein interaction network; NAFLD, non-alcoholic fatty liver disease; PCA, principal component analysis; biomarker; chronic liver disease; network biology; temporal gene expression profile

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article