A solid-phase approach for the synthesis of α-aminoboronic acid peptides.
RSC Adv
; 8(6): 3343-3347, 2018 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-35541192
ABSTRACT
A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described. Standard Fmoc solid-phase peptide chemistry is carried out to construct bortezomib and ixazomib. This approach eliminates the need for liquid-liquid extractions, silica gel column chromatography, and HPLC purifications, as products are isolated in high purity after direct cleavage from the resin.
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MEDLINE
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En
Ano de publicação:
2018
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Article