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Flavin catalyzed desulfurization of peptides and proteins in aqueous media.
Wan, Chuan; Yang, Dongyan; Qin, Xuan; Xue, Ziyi; Guo, Xiaochun; Hou, Zhanfeng; Jiang, Chenran; Yin, Feng; Wang, Rui; Li, Zigang.
Afiliação
  • Wan C; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. lizg.sz@pku.edu.cn.
  • Yang D; College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
  • Qin X; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. lizg.sz@pku.edu.cn.
  • Xue Z; College of chemistry & chemical engineering, Lanzhou University, Lanzhou, 730000, China.
  • Guo X; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. lizg.sz@pku.edu.cn.
  • Hou Z; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. lizg.sz@pku.edu.cn.
  • Jiang C; Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen, 518118, China. yinfeng@szbl.ac.cn.
  • Yin F; Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen, 518118, China. yinfeng@szbl.ac.cn.
  • Wang R; Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen, 518118, China. yinfeng@szbl.ac.cn.
  • Li Z; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, P. R. China. lizg.sz@pku.edu.cn.
Org Biomol Chem ; 20(20): 4105-4109, 2022 05 26.
Article em En | MEDLINE | ID: mdl-35546316
ABSTRACT
A biomimetic method has been established for the chemo-selective desulfurization of cysteinyl peptides and proteins in aqueous media. The derivatives of biocatalytic cofactors, flavins, were found to be efficient photosensitizers in a thiyl-radical-mediated desulfurization of Cys. The reaction was conducted in an ultrafast manner with both polypeptides and proteins.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Proteínas Idioma: En Ano de publicação: 2022 Tipo de documento: Article