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Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer.
Myer, Nicole M; Shitara, Kohei; Chung, Hyun C; Lordick, Florian; Kelly, Ronan J; Szabo, Zsolt; Cao, Z Alexander; Leong, Stephen; Ilson, David H; Weichert, Wilko.
Afiliação
  • Myer NM; Merck & Co., Inc., 90 E. Scott Avenue, Rahway, NJ, 07065, USA. nicole.myer@merck.com.
  • Shitara K; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
  • Chung HC; Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
  • Lordick F; Medical Department (Oncology, Gastroenterology, Hepatology, Pulmonology, and Infectious Diseases), University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany.
  • Kelly RJ; Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.
  • Szabo Z; Merck & Co., Inc., Ringstrasse 27 Kriens, LUZERN, 6010, Switzerland.
  • Cao ZA; Merck & Co., Inc., 90 E. Scott Avenue, Rahway, NJ, 07065, USA.
  • Leong S; Merck & Co., Inc., 351 N Sumneytown Pike, North Wales, PA, 19454, USA.
  • Ilson DH; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Weichert W; Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.
J Cancer Res Clin Oncol ; 148(8): 2023-2043, 2022 Aug.
Article em En | MEDLINE | ID: mdl-35551464
ABSTRACT
Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article