Diterpenoids from Blumea balsamifera and Their Anti-Inflammatory Activities.
Molecules
; 27(9)2022 Apr 30.
Article
em En
| MEDLINE
| ID: mdl-35566241
ABSTRACT
Six new diterpenoids, blusamiferoids A-F (1-6), including four pimarane-type diterpenoids, one rosane-type diterpenoid (3), and one rearranged abietane-type diterpenoid (6), were isolated from the dry aerial parts of Blumea balsamifera. Their structures were characterized by spectroscopic and computational methods. In particular, the structures of 1 and 4 were confirmed by X-ray crystallography. Compounds 5 and 6 were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound 5 also downregulated NF-κB phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asteraceae
/
Diterpenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article