Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids.
Molecules
; 27(9)2022 May 04.
Article
em En
| MEDLINE
| ID: mdl-35566289
ABSTRACT
Dihydrouracil presents a crucial intermediate in the catabolism of uracil. The vital importance of uracil and its nucleoside, uridine, encourages scientists to synthesize novel dihydrouracils. In this paper, we present an innovative, fast, and effective method for the synthesis of dihydrouracils. Hence, under mild conditions, 3-chloroperbenzoic acid was used to cleave the carbon-sulfur bond of the Biginelli hybrids 5,6-dihydropyrimidin-4(3H)-ones. This approach led to thirteen novel dihydrouracils synthesized in moderate-to-high yields (32-99%).
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Base de dados:
MEDLINE
Assunto principal:
Uracila
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article