Bing-Neel Syndrome Successfully Treated with Tirabrutinib.
Intern Med
; 61(23): 3575-3579, 2022 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-35569989
ABSTRACT
Bing-Neel syndrome (BNS) is a rare central nervous system manifestation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM). We herein report a 62-year-old man with LPL/WM after multiple chemotherapies. He had weakness of lower extremities and elevated serum IgM levels. A bone marrow examination showed lymphoplasmacytic cells infiltration. Contrast-enhanced magnetic resonance imaging suggested enhancing lesions in the cauda equina roots. He was diagnosed with BNS and started on treatment with tirabrutinib 480 mg daily. Within three months, he showed clinical and radiologic improvement. Tirabrutinib may have utility as an effective treatment for BNS.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
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Macroglobulinemia de Waldenstrom
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Doenças Neurodegenerativas
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article