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Antiproliferative and apoptotic potential of methotrexate lipid nanoparticles in a murine breast cancer model.
Surve, Chaitali; Banerjee, Ananya; S, Anupriya; Chakraborty, Rajasree; Kumar, Dhiraj; Butti, Ramesh; Gorain, Mahadeo; Parida, Sabyasachi; Kundu, Gopal C; Shidhaye, Supriya; Patnaik, Srinivas.
Afiliação
  • Surve C; Department of Pharmaceutics, Vivekanand Education Society's College of Pharmacy, Mumbai, India.
  • Banerjee A; Faculty of Pharmacy, Pacific Academy of Higher Education & Research University, Udaipur, Rajasthan, India.
  • S A; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
  • Chakraborty R; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
  • Kumar D; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
  • Butti R; National Centre for Cell Science (NCCS), NCCS Complex, Pune, Maharashtra, India.
  • Gorain M; National Centre for Cell Science (NCCS), NCCS Complex, Pune, Maharashtra, India.
  • Parida S; National Centre for Cell Science (NCCS), NCCS Complex, Pune, Maharashtra, India.
  • Kundu GC; Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha 24, India.
  • Shidhaye S; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
  • Patnaik S; National Centre for Cell Science (NCCS), NCCS Complex, Pune, Maharashtra, India.
Nanomedicine (Lond) ; 17(11): 753-764, 2022 05.
Article em En | MEDLINE | ID: mdl-35575008
ABSTRACT

Aim:

To evaluate the efficacy of novel methotrexate-loaded nanoparticles (MTX-NPs) in vitro and in vivo in the treatment of breast cancer. Materials &

methods:

MTX-NPs were tested for cellular uptake, cell viability, cell cycle, cellular wound migration and changes in tumor volume using characterized NPs.

Results:

The solid lipid NPs (SLNPs) showed strong cellular uptake, increased apoptosis, controlled cytotoxicity at lower IC50 of methotrexate and a sizable reduction in tumor burden.

Conclusion:

MTX-NP oral formulation can be a promising candidate in breast cancer treatment with improved cellular uptake and in vivo efficacy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Nanopartículas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Nanopartículas Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article