Phosphinic acid-based inhibitors of tubulin polyglycylation.
Chem Commun (Camb)
; 58(45): 6530-6533, 2022 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-35579270
ABSTRACT
Tubulin polyglycylation is a posttranslational modification that occurs primarily on the axonemes of flagella and cilia and has been shown to be essential for proper sperm motility. Inhibitors of both the initiase and elongase ligases (TTLL8 and TTLL10) are shown to inhibit tubulin glycylation in the low micromolar range.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Fosfínicos
/
Tubulina (Proteína)
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article