A platinum nanourchin-based multi-enzymatic platform to disrupt mitochondrial function assisted by modulating the intracellular H<sub>2</sub>O<sub>2</sub> homeostasis.

Huang, Jiansen; Li, Yongcan; Zhang, Lei; Wang, Jie; Xu, Zhigang; Kang, Yuejun; Xue, Peng

A platinum nanourchin-based multi-enzymatic platform to disrupt mitochondrial function assisted by modulating the intracellular H₂O₂ homeostasis.

Huang, Jiansen; Li, Yongcan; Zhang, Lei; Wang, Jie; Xu, Zhigang; Kang, Yuejun; Xue, Peng.

Afiliação

Huang J; School of Materials and Energy, Southwest University, Chongqing, 400715, China.
Li Y; School of Materials and Energy, Southwest University, Chongqing, 400715, China.
Zhang L; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Wang J; Cancer Center, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Xu Z; School of Materials and Energy, Southwest University, Chongqing, 400715, China.
Kang Y; School of Materials and Energy, Southwest University, Chongqing, 400715, China.
Xue P; School of Materials and Energy, Southwest University, Chongqing, 400715, China. Electronic address: xuepeng@swu.edu.cn.

Biomaterials ; 286: 121572, 2022 07.

Article em En | MEDLINE | ID: mdl-35580473

Assuntos

Peróxido de Hidrogênio; Neoplasias; Linhagem Celular Tumoral; Glucose/metabolismo; Glucose Oxidase/metabolismo; Homeostase; Humanos; Peróxido de Hidrogênio/metabolismo; Manganês/uso terapêutico; Mitocôndrias/metabolismo; Neoplasias/terapia; Platina/uso terapêutico; Espécies Reativas de Oxigênio/metabolismo; Microambiente Tumoral

Palavras-chave

Gas therapy; H(2)O(2) homeostasis; Mitochondrial damage; Tumor microenvironment; Tumor starvation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peróxido de Hidrogênio / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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