Physiological Functions of Intracellular Protein Degradation.
Annu Rev Cell Dev Biol
; 38: 241-262, 2022 10 06.
Article
em En
| MEDLINE
| ID: mdl-35587265
ABSTRACT
While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process Lysosomal, proteasomal, and mitochondrial degradation systems were identified and found to be involved in a staggering number of biological functions. Here, we provide a global overview of the diverse roles of cellular protein degradation using seven categories homeostasis, regulation, quality control, stoichiometry control, proteome remodeling, immune surveillance, and baseline turnover. Using selected examples, we outline how proteins are degraded and why this is functionally relevant.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Proteoma
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article