A host-gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood-brain barrier integrity <i>in vivo</i>.

Stachulski, Andrew V; Knausenberger, Tobias B-A; Shah, Sita N; Hoyles, Lesley; McArthur, Simon

A host-gut microbial amino acid co-metabolite, p-cresol glucuronide, promotes blood-brain barrier integrity in vivo.

Stachulski, Andrew V; Knausenberger, Tobias B-A; Shah, Sita N; Hoyles, Lesley; McArthur, Simon.

Afiliação

Stachulski AV; Department of Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, UK.
Knausenberger TB; Institute of Dentistry, Faculty of Medicine & Dentistry, Queen Mary, University of London, Blizard Institute, London, UK.
Shah SN; Institute of Dentistry, Faculty of Medicine & Dentistry, Queen Mary, University of London, Blizard Institute, London, UK.
Hoyles L; Department of Bioscience, School of Science and Technology, Nottingham Trent University, Clifton, Nottingham, UK.
McArthur S; Institute of Dentistry, Faculty of Medicine & Dentistry, Queen Mary, University of London, Blizard Institute, London, UK.

Tissue Barriers ; 11(1): 2073175, 2023 Jan 02.

Article em En | MEDLINE | ID: mdl-35596559

Assuntos

Barreira Hematoencefálica; Microbioma Gastrointestinal; Masculino; Camundongos; Humanos; Animais; Barreira Hematoencefálica/metabolismo; Glucuronídeos/metabolismo; Glucuronídeos/farmacologia; Aminoácidos/metabolismo; Aminoácidos/farmacologia; Lipopolissacarídeos/metabolismo; Lipopolissacarídeos/farmacologia

Palavras-chave

Bloodbrain barrier; glucuronidation; gut microbiota; gutbrain axis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Microbioma Gastrointestinal Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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