Characterising genome architectures using genome decomposition analysis.
BMC Genomics
; 23(1): 398, 2022 May 25.
Article
em En
| MEDLINE
| ID: mdl-35610562
ABSTRACT
Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes and underlie biological processes such as chromosomal segregation and the regulation of gene expression. We present a new tool called Genome Decomposition Analysis (GDA) that characterises genome architectures and acts as an accessible approach for discovering hidden features of a genome assembly. With the imminent deluge of high-quality genome assemblies from projects such as the Darwin Tree of Life and the Earth BioGenome Project, GDA has been designed to facilitate their exploration and the discovery of novel genome biology. We highlight the effectiveness of our approach in characterising the genome architectures of single-celled eukaryotic parasites from the phylum Apicomplexa and show that it scales well to large genomes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Parasitos
/
Apicomplexa
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article