A Nonoxidative Sequence for the Preparation of 1,2-Diketone Derivatives Using Aldehyde and Organometallic Building Blocks.
J Org Chem
; 87(12): 8213-8222, 2022 06 17.
Article
em En
| MEDLINE
| ID: mdl-35613467
This study investigates a synthetic sequence for the preparation of 1,2-diketone products. The sequence avoids oxidative conditions and instead employs reliable transformations including the Horner-Wadsworth-Emmons and addition of Grignard reagents to N-methyl-N-methoxy (Weinreb) amide intermediates. The reaction sequence is suitable for the synthesis of nonsymmetric aliphatic and aryl substituted derivatives.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aldeídos
/
Cetonas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article