Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines.
Chem Commun (Camb)
; 58(48): 6825-6828, 2022 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-35615964
ABSTRACT
We report herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, applying formates as a convenient carbonyl source. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines via an intramolecular reductive cyclization after the palladium-catalyzed process.
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MEDLINE
Idioma:
En
Ano de publicação:
2022
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Article