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Pi-inducedin-situaggregation of sevelamer nanoparticles for vascular embolization.
Bi, Qiu-Chen; Li, Yan-Shu; Luo, Rong-Guang; Chen, Hong; Lv, Yang-Feng; Liu, Zhi-Xing; Liang, Qing-Rong; Chen, Li; Xu, Bao-Hua; Tang, Qun.
Afiliação
  • Bi QC; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Li YS; Institute for Advanced Study, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Luo RG; Jiangxi Center of Medical Device Testing, Nanchang, 330029, People's Republic of China.
  • Chen H; Department of Medical Imaging and Interventional Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Lv YF; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Liu ZX; Jiangxi Provincial Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Liang QR; Institute for Advanced Study, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Chen L; Department of Ultrasonic Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.
  • Xu BH; Institute for Advanced Study, Nanchang University, Nanchang, 330031, People's Republic of China.
  • Tang Q; Department of Ultrasonic Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People's Republic of China.
Nanotechnology ; 33(35)2022 Jun 09.
Article em En | MEDLINE | ID: mdl-35616242
ABSTRACT
Decades have witnessed rapid progress of polymeric materials for vascular embolic or chemoembolic applications. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives,in situgelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackablein vivo. In this paper, we proposed a concept of 'responsive embolization'. Sevelamer, clinically proved as an inorganic phosphate binder, was ground into nanoparticles. Sevelamer nanoparticle is highly mobile and capable of swelling and aggregating in the presence of endogenous inorganic phosphate, thereby effectively occluding blood flow in the vessel as it was administered as an embolic agent for interventional therapy. Moreover, citrated sevelamer nanoparticles delayed the aggregation, preferable to penetrate deeply into the capillary system. On the rabbit VX2 liver cancer model, both sevelamer particles aggregates occlude the tumor feeding artery, but backflow was found for the pristine one, thereby citrate passivation of sevelamer nanoparticles endows it have potential from 'bench to bedside' as a new type of vascular embolic.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Embolização Terapêutica / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Embolização Terapêutica / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article