Microglia-mediated degradation of perineuronal nets promotes pain.
Science
; 377(6601): 80-86, 2022 07.
Article
em En
| MEDLINE
| ID: mdl-35617374
ABSTRACT
Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Microglia
/
Traumatismos dos Nervos Periféricos
/
Corno Dorsal da Medula Espinal
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Hiperalgesia
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article