CaMKII inhibition protects against hyperthyroid arrhythmias and adverse myocardial remodeling.
Biochem Biophys Res Commun
; 615: 136-142, 2022 07 30.
Article
em En
| MEDLINE
| ID: mdl-35617800
ABSTRACT
Hyperthyroidism can potentiate arrhythmias and cardiac hypertrophy, whereas Ca2+/calmodulin-dependent kinase II (CaMKII) promotes maladaptive myocardial remodeling. However, it remains unclear whether CaMKII contributes to the progression of hyperthyroid heart disease (HHD). This study demonstrated that CaMKII inhibition can relieve adverse myocardial remodeling and reduce sinus tachycardia, isoproterenol-induced atrial fibrillation, and ventricular arrhythmias in hyperthyroid mice with preserved heart function. Hyperthyroid cardiac hypertrophy was promoted by CaMKII upregulation-induced HDAC4/MEF2a activation. Briefly, CaMKII inhibition benefits HHD management greatly in mice by preventing arrhythmias and maladaptive remodeling.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Hipertireoidismo
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article