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Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Yshii, Lidia; Pasciuto, Emanuela; Bielefeld, Pascal; Mascali, Loriana; Lemaitre, Pierre; Marino, Marika; Dooley, James; Kouser, Lubna; Verschoren, Stijn; Lagou, Vasiliki; Kemps, Hannelore; Gervois, Pascal; de Boer, Antina; Burton, Oliver T; Wahis, Jérôme; Verhaert, Jens; Tareen, Samar H K; Roca, Carlos P; Singh, Kailash; Whyte, Carly E; Kerstens, Axelle; Callaerts-Vegh, Zsuzsanna; Poovathingal, Suresh; Prezzemolo, Teresa; Wierda, Keimpe; Dashwood, Amy; Xie, Junhua; Van Wonterghem, Elien; Creemers, Eline; Aloulou, Meryem; Gsell, Willy; Abiega, Oihane; Munck, Sebastian; Vandenbroucke, Roosmarijn E; Bronckaers, Annelies; Lemmens, Robin; De Strooper, Bart; Van Den Bosch, Ludo; Himmelreich, Uwe; Fitzsimons, Carlos P; Holt, Matthew G; Liston, Adrian.
Afiliação
  • Yshii L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Pasciuto E; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • Bielefeld P; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Mascali L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Lemaitre P; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • Marino M; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Dooley J; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands.
  • Kouser L; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Verschoren S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Lagou V; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • Kemps H; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Gervois P; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • de Boer A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Burton OT; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Wahis J; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Verhaert J; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Tareen SHK; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Roca CP; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Singh K; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Whyte CE; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • Kerstens A; Cardio & Organ Systems (COST), Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium.
  • Callaerts-Vegh Z; Cardio & Organ Systems (COST), Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium.
  • Poovathingal S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Prezzemolo T; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Wierda K; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Dashwood A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Xie J; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Van Wonterghem E; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Creemers E; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Aloulou M; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Gsell W; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Abiega O; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Munck S; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.
  • Vandenbroucke RE; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Bronckaers A; KU Leuven - Department of Neurosciences, Leuven, Belgium.
  • Lemmens R; VIB Bio-Imaging Core, Leuven, Belgium.
  • De Strooper B; KU Leuven, Faculty of Psychology, Laboratory of Biological Psychology, Leuven, Belgium.
  • Van Den Bosch L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Himmelreich U; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Fitzsimons CP; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.
  • Holt MG; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.
  • Liston A; KU Leuven - Department of Neurosciences, Leuven, Belgium.
Nat Immunol ; 23(6): 878-891, 2022 06.
Article em En | MEDLINE | ID: mdl-35618831
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Astrócitos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Astrócitos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article