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Transcribed Ultraconserved Regions in Cancer.
Gibert, Myron K; Sarkar, Aditya; Chagari, Bilhan; Roig-Laboy, Christian; Saha, Shekhar; Bednarek, Sylwia; Kefas, Benjamin; Hanif, Farina; Hudson, Kadie; Dube, Collin; Zhang, Ying; Abounader, Roger.
Afiliação
  • Gibert MK; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Sarkar A; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Chagari B; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Roig-Laboy C; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Saha S; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Bednarek S; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Kefas B; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Hanif F; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Hudson K; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Dube C; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Zhang Y; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
  • Abounader R; Department of Microbiology, Immunology, and Cancer Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Cells ; 11(10)2022 05 19.
Article em En | MEDLINE | ID: mdl-35626721
ABSTRACT
Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Longo não Codificante / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article