Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children.
Int J Mol Sci
; 23(10)2022 May 18.
Article
em En
| MEDLINE
| ID: mdl-35628461
ABSTRACT
Peritoneal dialysis (PD) represents the dialysis modality of choice for pediatric patients with end-stage kidney disease. Indeed, compared with hemodialysis (HD), it offers many advantages, including more flexibility, reduction of the risk of hospital-acquired infections, preservation of residual kidney function, and a better quality of life. However, despite these positive aspects, PD may be associated with several long-term complications that may impair both patient's general health and PD adequacy. In this view, chronic inflammation, caused by different factors, has a detrimental impact on the structure and function of the peritoneal membrane, leading to sclerosis and consequent PD failure both in adults and children. Although several studies investigated the complex pathogenic pathways underlying peritoneal membrane alterations, these processes remain still to explore. Understanding these mechanisms may provide novel approaches to improve the clinical outcome of pediatric PD patients through the identification of subjects at high risk of complications and the implementation of personalized interventions. In this review, we discuss the main experimental and clinical experiences exploring the potentiality of the proteomic analysis of peritoneal fluids and extracellular vesicles as a source of novel biomarkers in pediatric peritoneal dialysis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diálise Peritoneal
/
Vesículas Extracelulares
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Child
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Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article