Your browser doesn't support javascript.
loading
Mussel-Inspired Multicomponent Codeposition Strategy toward Antibacterial and Lubricating Multifunctional Coatings on Bioimplants.
Zhang, Yixin; Jiang, Wei; Lei, Lele; Wang, Ying; Xu, Rongnian; Qin, Long; Wei, Qiangbing.
Afiliação
  • Zhang Y; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Jiang W; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Lei L; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Wang Y; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Xu R; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
  • Qin L; Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
  • Wei Q; Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China.
Langmuir ; 38(23): 7157-7167, 2022 06 14.
Article em En | MEDLINE | ID: mdl-35635328
Bacterial infections and limited surface lubrication are the two key challenges for bioimplants in dynamic contact with tissues. However, the simultaneous lubricating and antibacterial properties of the bioimplants have rarely been investigated. In this work, we successfully developed a multifunctional coating with simultaneous antibacterial and lubricating properties for surface functionalization of bioimplant materials. The multifunctional coating was fabricated on a polyurethane (PU) substrate via polydopamine (PDA)-assisted multicomponent codeposition, containing polyethyleneimine (PEI) and trace amounts of copper (Cu) as synergistic antibacterial components and zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as the lubricating component. The obtained PDA(Cu)/PEI/PMPC coating showed excellent antibacterial activity (antibacterial efficiency: ∼99%) to both Escherichia coli and Staphylococcus aureus compared with bare PU. The excellent antibacterial properties were attributed to the combined effect of anti-adhesion capability of hydrophilic PMPC and PEI and bactericidal activity of Cu in the coating. Meanwhile, the coefficient of friction of the coating was significantly decreased by ∼52% compared with bare PU owing to the high hydration feature of PMPC, suggesting the superior lubricating property. Furthermore, the PDA(Cu)/PEI/PMPC coating was highly biocompatible toward human umbilical vein endothelial cells demonstrated by in vitro cytotoxicity tests. This study not only contributes to the chemistry of PDA-assisted multicomponent codeposition but also provides a facile and practical way for rational design of multifunctional coatings for medical devices.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Células Endoteliais Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Células Endoteliais Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article