Application of empirical scalars to enable early prediction of human hepatic clearance using IVIVE in drug discovery: an evaluation of 173 drugs.

Jones, Robert S; Leung, Christian; Chang, Jae H; Brown, Suzanne; Liu, Ning; Yan, Zhengyin; Kenny, Jane R; Broccatelli, Fabio

Jones, Robert S; Leung, Christian; Chang, Jae H; Brown, Suzanne; Liu, Ning; Yan, Zhengyin; Kenny, Jane R; Broccatelli, Fabio.

Afiliação

Jones RS; Genentech, Inc, United States jones.robert@gene.com.
Leung C; Genentech, United States.
Chang JH; Preclinical Development Sciences, ORIC Pharmaceuticals, United States.
Brown S; Ultragenyx Pharmaceutical, United States.
Liu N; Avirmax, Inc., United States.
Yan Z; DMPK, Genentech INC, United States.
Kenny JR; Drug Metabolism & Pharmacokinetics, Genentech Inc, United States.
Broccatelli F; Genentech, United States.

Drug Metab Dispos ; 2022 May 30.

Article em En | MEDLINE | ID: mdl-35636770

Palavras-chave

drug clearance; hepatic elimination; in vitro-in vivo prediction (IVIVE); in vitro-in vivo scaling; plasma protein binding

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article