Increased Tacrolimus Exposure in Kidney Transplant Recipients With COVID-19: Inflammation-Driven Downregulation of Metabolism as a Potential Mechanism.

Klomp, Sylvia D; Meziyerh, Soufian; Vissers, Maurits F J M; Moes, Dirk J A R; Arends, Eline J; Teng, Y K Onno; Swen, Jesse J; de Vries, Aiko P J

Klomp, Sylvia D; Meziyerh, Soufian; Vissers, Maurits F J M; Moes, Dirk J A R; Arends, Eline J; Teng, Y K Onno; Swen, Jesse J; de Vries, Aiko P J.

Afiliação

Klomp SD; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands.
Meziyerh S; Leiden Network for Personalised Therapeutics, Leiden University Medical Center, Leiden, Netherlands.
Vissers MFJM; Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Moes DJAR; Leiden Transplant Center, Leiden University Medical Center, Leiden, Netherlands.
Arends EJ; Centre for Human Drug Research, Leiden, Netherlands.
Teng YKO; Leiden University Medical Center, Leiden, Netherlands.
Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands.
de Vries APJ; Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, Netherlands.

Transpl Int ; 35: 10269, 2022.

Article em En | MEDLINE | ID: mdl-35651879

Assuntos

COVID-19; Transplante de Rim; Regulação para Baixo; Humanos; Inflamação/etiologia; Transplante de Rim/efeitos adversos; Tacrolimo/efeitos adversos

Palavras-chave

COVID-19; CYP3A; Tacrolimus; kidney transplant; metabolism; phenoconversion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Rim / COVID-19 Tipo de estudo: Etiology_studies / Guideline Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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