Synthesis of fused polycyclic ß-carboline derivatives using Ugi-4CR followed by cascade cyclization.
Mol Divers
; 27(2): 951-957, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-35652975
ABSTRACT
Ugi-four component reaction (Ugi-4CR) is extremely attractive for diversity-oriented and step economical synthesis as evident from past applications. Here we report the synthesis of fused polycyclic ß-carboline derivatives by sequential Pictet-Spengler's and Ugi-4CR multi-component reaction followed by cascade cyclization. The post cyclisation of Ugi product provides conformationally stable heterocyclic molecule that is expected to be suitable for interaction with different biological targets. The methodology provides a simple and facile access to heterocycles embedded in polycyclic framework which otherwise seems difficult to synthesize by conventional methods. Synthesis of fused Polycyclic ß-Carboline Derivatives Using Ugi-4CR Followed by Cascade Cyclization.
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Base de dados:
MEDLINE
Assunto principal:
Carbolinas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article