c-Src-mediated phosphorylation and activation of kinesin KIF1C promotes elongation of invadopodia in cancer cells.

Saji, Takeshi; Nishita, Michiru; Ikeda, Kazuho; Endo, Mitsuharu; Okada, Yasushi; Minami, Yasuhiro

Saji, Takeshi; Nishita, Michiru; Ikeda, Kazuho; Endo, Mitsuharu; Okada, Yasushi; Minami, Yasuhiro.

Afiliação

Saji T; Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan; Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan.
Nishita M; Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan; Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan. Electronic address: nishita@fmu.ac.jp.
Ikeda K; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Endo M; Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan.
Okada Y; Department of Cell Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Laboratory for Cell Polarity Regulation, RIKEN Center for Biosystems Dynamics Research (BDR), Osaka, Japan; Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan; Univer
Minami Y; Division of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan. Electronic address: minami@kobe-u.ac.jp.

J Biol Chem ; 298(7): 102090, 2022 07.

Article em En | MEDLINE | ID: mdl-35654143

Assuntos

Genes src; Cinesinas; Invasividade Neoplásica; Podossomos; Linhagem Celular Tumoral; Humanos; Cinesinas/genética; Microtúbulos/metabolismo; Fosforilação; Podossomos/metabolismo; Proteínas Tirosina Fosfatases não Receptoras; Tirosina/metabolismo

Palavras-chave

KIF1C; Src; cell invasion; invadopodia; kinesin; microtubule; phosphorylation; tumor cell biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Genes src / Cinesinas / Podossomos / Invasividade Neoplásica Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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