RNA modifications can affect RNase H1-mediated PS-ASO activity.

Doxtader Lacy, Katelyn A; Liang, Xue-Hai; Zhang, Lingdi; Crooke, Stanley T.

Afiliação

Doxtader Lacy KA; Core Antisense Research Ionis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA.
Liang XH; Core Antisense Research Ionis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA.
Zhang L; Core Antisense Research Ionis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA.
Crooke ST; Core Antisense Research Ionis Pharmaceuticals, Inc, Carlsbad, CA 92008, USA.

Mol Ther Nucleic Acids ; 28: 814-828, 2022 Jun 14.

Article em En | MEDLINE | ID: mdl-35664704