A Highly Water- and Air-Stable Iron-Containing MRI Contrast Agent Sensor for H2 O2.
Chemistry
; 28(46): e202201179, 2022 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-35666136
ABSTRACT
A highly water- and air-stable Fe(II) complex with the quinol-containing macrocyclic ligand H4 qp4 reacts with H2 O2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para-quinones. The reaction increases the T1 -weighted relaxivity over four-fold, enabling the complex to detect H2 O2 using clinical MRI technology. The iron-containing sensor differs from its recently characterized manganese analog, which also detects H2 O2 , in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity.
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Base de dados:
MEDLINE
Assunto principal:
Meios de Contraste
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Ferro
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article