Nucleus pulposus cell senescence is regulated by substrate stiffness and is alleviated by LOX possibly through the integrin ß1-p38 MAPK signaling pathway.

Zhao, Runze; Yang, Li; He, Shuangjian; Xia, Tingting

Zhao, Runze; Yang, Li; He, Shuangjian; Xia, Tingting.

Afiliação

Zhao R; Department of Orthopedic Surgery, The First Affiliated Hospital, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Yang L; Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China.
He S; Department of Orthopedics, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, 215153, Jiangsu, China. Electronic address: heshuangjian@njmu.edu.cn.
Xia T; Institute of Clinical Medicine Research, The Affiliated Suzhou Science and Technology Town Hospital of Nanjing Medical University, Suzhou, 215153, Jiangsu, China. Electronic address: xtt92@njmu.edu.cn.

Exp Cell Res ; 417(2): 113230, 2022 08 15.

Article em En | MEDLINE | ID: mdl-35667466

Assuntos

Degeneração do Disco Intervertebral; Núcleo Pulposo; Animais; Células Cultivadas; Senescência Celular; Integrina beta1/genética; Integrina beta1/metabolismo; Degeneração do Disco Intervertebral/metabolismo; Núcleo Pulposo/metabolismo; Proteína-Lisina 6-Oxidase/genética; Proteína-Lisina 6-Oxidase/metabolismo; Proteína-Lisina 6-Oxidase/farmacologia; Ratos; Transdução de Sinais; Proteínas Quinases p38 Ativadas por Mitógeno/genética; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Cellular Young's modulus; Integrin ß1-p38 MAPK signaling; LOX; NP cell Senescence; Substrate stiffness

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração do Disco Intervertebral / Núcleo Pulposo Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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