Pituitary acting drugs: cabergoline and pasireotide.
Pituitary
; 25(5): 722-725, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35670988
ABSTRACT
First-line treatment for Cushing´s disease is transsphenoidal surgery. But in cases of persistent or recurrent disease after surgery, contraindications to surgery, severe hypercortisolism control before surgery, or for patients waiting for radiotherapy effects, medical therapy may be indicated. Pituitary-directed agents include cabergoline and pasireotide. Both drugs present similar potential for biochemical control and pasireotide has additionally been proved to reduce tumor volume. Moreover, pasireotide was evaluated in high quality studies. In respect to safety, both drugs are well tolerated and safe, but special attention should be given for cardiac valve disease and psychiatric disorder for cabergoline, and hyperglycemia for pasireotide.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Somatostatina
/
Hipersecreção Hipofisária de ACTH
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Cabergolina
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article