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Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats.
Chen, Rongchang; Xu, Lijiao; Zhang, Xu; Sun, Guibo; Zeng, Wenying; Sun, Xiaobo.
Afiliação
  • Chen R; MD. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.
  • Xu L; MM. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.
  • Zhang X; MD. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.
  • Sun G; MD. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.
  • Zeng W; MD. Xiyuan Hospital - Department of Comprehensive Medicine - Beijing, China.
  • Sun X; MD. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.
Acta Cir Bras ; 37(3): e370304, 2022.
Article em En | MEDLINE | ID: mdl-35674582
PURPOSE: To investigate the protective effects of Shenkang injection (SKI) on adenine-induced chronic renal failure (CRF) in rat. METHODS: Sprague Dawley rats were randomly divided into five groups: control, model, and SKI groups (5, 10, 20 mL/kg). Rats in model and SKI groups were treated with adenine i.g. at a dose of 150 mg/kg every day for 12 weeks to induce CRF. Twelve weeks later, SKI was administered to the rat i.p. for four weeks. The effects of SKI on kidney injury and fibrosis were detected. RESULTS: SKI inhibited the elevation of the urine level of N-acetyl-b-D-glucosaminidase, kidney injury molecule-1, beta-2-microglobulin, urea protein in CRF rats. The serum levels of uric acid and serum creatinine increased and albumin decreased in the model group, which was prevented by SKI. SKI inhibited the release of inflammatory cytokines and increasing the activities of antioxidant enzymes in serum. SKI inhibited the expression of transforming growth factor-ß1, vascular cell adhesion molecule 1, intercellular adhesion molecule 1, collagen I, collagen III, endothelin-1, laminin in kidney of CRF rats. CONCLUSIONS: SKI protected against adenine-induced kidney injury and fibrosis and exerted anti-inflammatory, and antioxidant effects in CRF rats.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Falência Renal Crônica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Falência Renal Crônica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article