NLRP3 Inflammasome Negatively Regulates RANKL-Induced Osteoclastogenesis of Mouse Bone Marrow Macrophages but Positively Regulates It in the Presence of Lipopolysaccharides.

Alam, Mohammad Ibtehaz; Mae, Megumi; Farhana, Fatima; Oohira, Masayuki; Yamashita, Yasunori; Ozaki, Yukio; Sakai, Eiko; Yoshimura, Atsutoshi

Alam, Mohammad Ibtehaz; Mae, Megumi; Farhana, Fatima; Oohira, Masayuki; Yamashita, Yasunori; Ozaki, Yukio; Sakai, Eiko; Yoshimura, Atsutoshi.

Afiliação

Alam MI; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Mae M; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Farhana F; Department of Dental Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Oohira M; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Yamashita Y; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Ozaki Y; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Sakai E; Department of Dental Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.
Yoshimura A; Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan.

Int J Mol Sci ; 23(11)2022 May 29.

Article em En | MEDLINE | ID: mdl-35682777

Assuntos

Inflamassomos; Lipopolissacarídeos; Animais; Medula Óssea/metabolismo; Caspase 1/metabolismo; Inflamassomos/metabolismo; Interleucina-1beta/metabolismo; Lipopolissacarídeos/metabolismo; Lipopolissacarídeos/farmacologia; Macrófagos/metabolismo; Camundongos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Osteogênese; Ligante RANK/metabolismo; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

NLRP3 inflammasome; RANKL; bone remodeling; interleukin-1ß; osteoclast; pyroptosis; reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Inflamassomos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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