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New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study.
Climova, Alina; Pivovarova, Ekaterina; Rogalewicz, Bartlomiej; Raducka, Anita; Szczesio, Malgorzata; Korona-Glowniak, Izabela; Korga-Plewko, Agnieszka; Iwan, Magdalena; Gobis, Katarzyna; Czylkowska, Agnieszka.
Afiliação
  • Climova A; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  • Pivovarova E; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  • Rogalewicz B; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  • Raducka A; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  • Szczesio M; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
  • Korona-Glowniak I; Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Korga-Plewko A; Independent Medical Biology Unit, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland.
  • Iwan M; Department of Toxicology, Medical University of Lublin, Chodzki 6, 20-093 Lublin, Poland.
  • Gobis K; Department of Organic Chemistry, Medical University of Gdansk, 107 Gen. Hallera Av., 80-438 Gdansk, Poland.
  • Czylkowska A; Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Molecules ; 27(11)2022 May 27.
Article em En | MEDLINE | ID: mdl-35684404
ABSTRACT
New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N'-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques elemental analysis (EA), thermogravimetric analysis (TG-DTG), infrared spectroscopy (FTIR), and flame-atomic absorption spectrometry (F-AAS). The biological activity of the obtained compounds was then comprehensively investigated. Rational use of these compounds as potential drugs was proven by ADME analysis. All obtained compounds were screened in vitro for antibacterial, antifungal, and anticancer activities. Some of the studied complexes exhibited significantly higher activity than the ligand alone.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexos de Coordenação Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexos de Coordenação Idioma: En Ano de publicação: 2022 Tipo de documento: Article