Extracellular Hsp90&#945; stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.

Okusha, Yuka; Lang, Benjamin J; Murshid, Ayesha; Borges, Thiago J; Holton, Kristina M; Clark-Matott, Joanne; Doshi, Sachin; Ikezu, Tsuneya; Calderwood, Stuart K

Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.

Okusha, Yuka; Lang, Benjamin J; Murshid, Ayesha; Borges, Thiago J; Holton, Kristina M; Clark-Matott, Joanne; Doshi, Sachin; Ikezu, Tsuneya; Calderwood, Stuart K.

Afiliação

Okusha Y; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. yokusha@bidmc.harvard.edu.
Lang BJ; JSPS Overseas Research Fellowship, Tokyo, 102-0083, Japan. yokusha@bidmc.harvard.edu.
Murshid A; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Borges TJ; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Holton KM; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Clark-Matott J; Research Computing, Harvard Medical School, Boston, MA, 02215, USA.
Doshi S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, 02138, USA.
Ikezu T; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Calderwood SK; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

Cell Stress Chaperones ; 27(5): 461-478, 2022 09.

Article em En | MEDLINE | ID: mdl-35689138

Assuntos

Microglia; Doenças Neurodegenerativas; Peptídeos beta-Amiloides/toxicidade; Meios de Cultivo Condicionados/farmacologia; Proteínas de Choque Térmico HSP90; Proteínas de Choque Térmico/metabolismo; Humanos; Lipopolissacarídeos/metabolismo; Lipopolissacarídeos/toxicidade; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/metabolismo; Doenças Neurodegenerativas/metabolismo; Óxido Nítrico/metabolismo; Estresse Oxidativo

Palavras-chave

Amyloid-beta; Extracellular HSPs; Hsp90; Inflammation; Marco; Microglia; NF-kB; Nrf2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / Doenças Neurodegenerativas Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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