Ca2+ as a coordinator of skeletal muscle differentiation, fusion and contraction.
FEBS J
; 289(21): 6531-6542, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35689496
ABSTRACT
Muscle regeneration is essential for vertebrate muscle homeostasis and recovery after injury. During regeneration, muscle stem cells differentiate into myocytes, which then fuse with pre-existing muscle fibres. Hence, differentiation, fusion and contraction must be tightly regulated during regeneration to avoid the disastrous consequences of premature fusion of myocytes to actively contracting fibres. Cytosolic calcium (Ca2+ ), which is coupled to both induction of myogenic differentiation and contraction, has more recently been implicated in the regulation of myocyte-to-myotube fusion. In this viewpoint, we propose that Ca2+ -mediated coordination of differentiation, fusion and contraction is a feature selected in the amniotes to facilitate muscle regeneration.
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Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Desenvolvimento Muscular
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article