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Exploration of 4-(1H-indol-3-yl)cyclohex-3-en-1-amine analogues as HDAC inhibitors: Design, synthesis, biological evaluation and modelling studies.
Zhu, Chengze; Liu, Mingyue; Yuan, Yue; Chen, Huanhua; Wu, Limeng; Cong, Zizheng; Zhao, Qingchun; Ding, Huaiwei.
Afiliação
  • Zhu C; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Liu M; School of Life Science and Biochemistry, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Yuan Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Chen H; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Wu L; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Cong Z; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China.
  • Zhao Q; School of Life Science and Biochemistry, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China; Department of Pharmancy, General Hospital of Northern Theater Command, Shenyang 110840, China. Electronic address: Zhaoqingchun@syphu.edu.cn.
  • Ding H; Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning 110016, PR China. Electronic address: dinghuaiwei627@163.com.
Bioorg Med Chem Lett ; 72: 128846, 2022 09 15.
Article em En | MEDLINE | ID: mdl-35697181
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article