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Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters.
Stark, Felicity C; Akache, Bassel; Deschatelets, Lise; Tran, Anh; Stuible, Matthew; Durocher, Yves; McCluskie, Michael J; Agbayani, Gerard; Dudani, Renu; Harrison, Blair A; Renner, Tyler M; Makinen, Shawn R; Bavananthasivam, Jegarubee; Duque, Diana; Gagne, Martin; Zimmermann, Joseph; Zarley, C David; Cochrane, Terrence R; Handfield, Martin.
Afiliação
  • Stark FC; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Akache B; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada. Bassel.akache@nrc-cnrc.gc.ca.
  • Deschatelets L; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Tran A; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Stuible M; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Durocher Y; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • McCluskie MJ; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Agbayani G; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Dudani R; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Harrison BA; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Renner TM; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Makinen SR; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Bavananthasivam J; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Duque D; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
  • Gagne M; Biodextris Inc., 525 boul. Cartier West, Laval, QC, H7V 3S8, Canada.
  • Zimmermann J; Inspirevax Inc., 46 rue de Saint-Tropez, Kirkland, QC, H9J 2K6, Canada.
  • Zarley CD; Oragenics, Inc., 13700 Progress Blvd, Alachua, FL, 32608, USA.
  • Cochrane TR; CDZarley LLC., 133 Butternut Dr, Pottstown, PA, 19464, USA.
  • Handfield M; Oragenics, Inc., 13700 Progress Blvd, Alachua, FL, 32608, USA.
Sci Rep ; 12(1): 9772, 2022 06 13.
Article em En | MEDLINE | ID: mdl-35697917
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteína da Espícula de Coronavírus / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteína da Espícula de Coronavírus / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article