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Comparison of 6-month outcomes of sepsis versus non-sepsis critically ill patients receiving mechanical ventilation.
Hodgson, Carol L; Higgins, Alisa M; Bailey, Michael; Barrett, Jonathon; Bellomo, Rinaldo; Cooper, D James; Gabbe, Belinda J; Iwashyna, Theodore; Linke, Natalie; Myles, Paul S; Paton, Michelle; Philpot, Steve; Shulman, Mark; Young, Meredith; Serpa Neto, Ary.
Afiliação
  • Hodgson CL; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia. carol.hodgson@monash.edu.
  • Higgins AM; Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia. carol.hodgson@monash.edu.
  • Bailey M; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
  • Barrett J; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
  • Bellomo R; Intensive Care Unit, Epworth Healthcare, Melbourne, VIC, Australia.
  • Cooper DJ; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
  • Gabbe BJ; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
  • Iwashyna T; Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia.
  • Linke N; Department of Intensive Care, Austin Health, Melbourne, VIC, Australia.
  • Myles PS; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
  • Paton M; Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia.
  • Philpot S; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
  • Shulman M; Division of Pulmonary and Critical Care, Department of Medicine, University of Michigan, Ann Arbor, USA.
  • Young M; Centre for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA.
  • Serpa Neto A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
Crit Care ; 26(1): 174, 2022 06 13.
Article em En | MEDLINE | ID: mdl-35698201
BACKGROUND: Data on long-term outcomes after sepsis-associated critical illness have mostly come from small cohort studies, with no information about the incidence of new disability. We investigated whether sepsis-associated critical illness was independently associated with new disability at 6 months after ICU admission compared with other types of critical illness. METHODS: We conducted a secondary analysis of a multicenter, prospective cohort study in six metropolitan intensive care units in Australia. Adult patients were eligible if they had been admitted to the ICU and received more than 24 h of mechanical ventilation. There was no intervention. RESULTS: The primary outcome was new disability measured with the WHO Disability Assessment Schedule 2.0 (WHODAS) 12 level score compared between baseline and 6 months. Between enrollment and follow-up at 6 months, 222/888 (25%) patients died, 100 (35.5%) with sepsis and 122 (20.1%) without sepsis (P < 0.001). Among survivors, there was no difference for the incidence of new disability at 6 months with or without sepsis, 42/106 (39.6%) and 106/300 (35.3%) (RD, 0.00 (- 10.29 to 10.40), P = 0.995), respectively. In addition, there was no difference in the severity of disability, health-related quality of life, anxiety and depression, post-traumatic stress, return to work, financial distress or cognitive function. CONCLUSIONS: Compared to mechanically ventilated patients of similar acuity and length of stay without sepsis, patients with sepsis admitted to ICU have an increased risk of death, but survivors have a similar risk of new disability at 6 months. Trial registration NCT03226912, registered July 24, 2017.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Terminal / Sepse Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Terminal / Sepse Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article