The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China.
Int J Infect Dis
; 122: 321-326.2, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35700876
ABSTRACT
OBJECTIVES:
In this study, we aimed to verify whether Bacillus Calmette-Guérin (BCG) can protect first-year college students against Mycobacterium tuberculosis (MTB) infection by the recombinant fusion protein ESAT6-CFP10 skin test (ECST) or the tuberculin skin test (TST).METHODS:
We conducted a cross-sectional study to assess risk factors for latent tuberculosis infection (LTBI). Vaccine effectiveness of BCG against LTBI, measured by ECST and TST separately, was assessed using multivariable logistic regression.RESULTS:
A total of 7351 college freshmen accepted ECST, whereas 7228 accepted TST. A total of 263 (3.58%) tested positive with ECST and 581 (8.04%) tested positive with TST. BCG was significantly associated with LTBI (ECST adjusted odds ratio (aOR) = 0.26; 95% CI 0.09 to 0.73; TST aOR = 0.25; 95% CI 0.13 to 0.49). The BCG protective effect on freshmen living in rural areas (ECST aOR = 0.16; 95% CI 0.04 to 0.55; TST aOR = 0.12; 95% CI 0.04 to 0.33) is better than that of freshmen living in cities (ECST aOR = 0.53; 95% CI 0.07 to 4.03; TST aOR = 0.44; 95% CI 0.17 to 1.16).CONCLUSIONS:
Protection against LTBI was strongly associated with BCG vaccination. A novel skin test (ECST) may underestimate the protective effects of BCG in college freshmen. BCG has better protection in areas with a slightly higher incidence of LTBI.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Tuberculose Latente
/
Mycobacterium bovis
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article