Swertiamarin-mediated immune modulation/adaptation confers protection against Plasmodium berghei.
Future Microbiol
; 17: 931-941, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-35704297
ABSTRACT
Aims:
Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. Materials &methods:
We carried out studies in Swiss albino mice that received infectious challenge with Plasmodium berghei and swertiamarin treatment in a prophylactic manner. Results &conclusion:
Oral administration of swertiamarin prior to infectious challenge with P. berghei in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Plasmodium berghei
/
Antimaláricos
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article