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Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
Nefzger, Christian M; Jardé, Thierry; Srivastava, Akanksha; Schroeder, Jan; Rossello, Fernando J; Horvay, Katja; Prasko, Mirsada; Paynter, Jacob M; Chen, Joseph; Weng, Chen-Fang; Sun, Yu B Y; Liu, Xiaodong; Chan, Eva; Deshpande, Nikita; Chen, Xiaoli; Li, Y Jinhua; Pflueger, Jahnvi; Engel, Rebekah M; Knaupp, Anja S; Tsyganov, Kirill; Nilsson, Susan K; Lister, Ryan; Rackham, Owen J L; Abud, Helen E; Polo, Jose M.
Afiliação
  • Nefzger CM; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Jardé T; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
  • Srivastava A; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Schroeder J; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia.
  • Rossello FJ; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Horvay K; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Prasko M; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Paynter JM; Australian Research Council Centre of Excellence in Plant Energy Biology, School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
  • Chen J; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Weng CF; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
  • Sun YBY; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Liu X; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Chan E; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
  • Deshpande N; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Chen X; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Li YJ; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Pflueger J; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Engel RM; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Knaupp AS; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Tsyganov K; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Nilsson SK; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Lister R; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
  • Rackham OJL; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
  • Abud HE; Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
  • Polo JM; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
NPJ Regen Med ; 7(1): 31, 2022 Jun 16.
Article em En | MEDLINE | ID: mdl-35710627
ABSTRACT
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article