[Lignans from Agrimonia pilosa].
Zhongguo Zhong Yao Za Zhi
; 47(11): 2982-2988, 2022 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-35718520
ABSTRACT
Thirteen lignans were isolated from 60% ethanol extract of Agrimonia pilosa by column chromatography over silica gel, ODS, and MCI and preparative high performance liquid chromatography(HPLC). Their chemical structures were identified by physiochemical properties and spectral data as(7S,8S)-threo-4,7,9,9'-tetrahydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan(1),(+)-4,9,9'-trihydroxy-3-methoxy-3',7-epoxy-8,4'-oxyneolignan(2), dihydrodehydro-diconiferyl alcohol(3), 4,9,9'-trihydroxy-3,3',5-trimethoxy-4',7-epoxy-8,5'-neolignan(4),(-)-secoisolariciresinol(5), 4,7,9,9'-tetrahydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan(6),(+)-isolariciresinol(7), 4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan(8), burselignan(9),(-)-evofolin B(10), icariol A2(11), ciwujiatone(12), and(+)-4â³,4î-dihydroxy-3,3',3â³,3î,5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8â³;4',8î-bisoxy-8,8'-dineolignan-7â³,7î,9â³,9î-tetraol(13). Compound 1 was a new compound, and compounds 1-13 were isolated from Agrimonia plant for the first time. This study can enrich the chemical components in A. pilosa and provide material conditions for the follow-up study of its biological activity and the elucidation of its pharmacodynamic substances.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Agrimonia
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article