Blood flow meets mitophagy.

Akmeriç, Emir Bora; Gerhardt, Holger

Akmeriç, Emir Bora; Gerhardt, Holger.

Afiliação

Akmeriç EB; Integrative Vascular Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Gerhardt H; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Germany.

J Cell Biol ; 221(7)2022 07 04.

Article em En | MEDLINE | ID: mdl-35727256

ABSTRACT

ABSTRACT

Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2's varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol.https//doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2's transcriptional dynamics.

Assuntos

Fatores de Transcrição Kruppel-Like; Mitocôndrias; Mitofagia; Animais; Humanos; Fatores de Transcrição Kruppel-Like/metabolismo; Camundongos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição Kruppel-Like / Mitofagia / Mitocôndrias Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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