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Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke, Katja; Obermayer, Benedikt; Mache, Christin; Fatykhova, Diana; Kessler, Mirjana; Dökel, Simon; Wyler, Emanuel; Baumgardt, Morris; Löwa, Anna; Hoffmann, Karen; Graff, Patrick; Schulze, Jessica; Mieth, Maren; Hellwig, Katharina; Demir, Zeynep; Biere, Barbara; Brunotte, Linda; Mecate-Zambrano, Angeles; Bushe, Judith; Dohmen, Melanie; Hinze, Christian; Elezkurtaj, Sefer; Tönnies, Mario; Bauer, Torsten T; Eggeling, Stephan; Tran, Hong-Linh; Schneider, Paul; Neudecker, Jens; Rückert, Jens C; Schmidt-Ott, Kai M; Busch, Jonas; Klauschen, Frederick; Horst, David; Radbruch, Helena; Radke, Josefine; Heppner, Frank; Corman, Victor M; Niemeyer, Daniela; Müller, Marcel A; Goffinet, Christine; Mothes, Ronja; Pascual-Reguant, Anna; Hauser, Anja Erika; Beule, Dieter; Landthaler, Markus; Ludwig, Stephan; Suttorp, Norbert; Witzenrath, Martin; Gruber, Achim D; Drosten, Christian.
Afiliação
  • Hönzke K; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Obermayer B; Contributed equally.
  • Mache C; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Core Unit Bioinformatics, Berlin, Germany.
  • Fatykhova D; Contributed equally.
  • Kessler M; Unit 17 "Influenza and other Respiratory Viruses", Robert Koch Institut, Berlin, Germany.
  • Dökel S; Contributed equally.
  • Wyler E; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Baumgardt M; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Löwa A; Department of Gynecology and Obstetrics, Ludwig-Maximilian University, Munich, Germany.
  • Hoffmann K; Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
  • Graff P; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and IRI Life Sciences, Institute for Biology, Humboldt Universität zu Berlin, Berlin, Germany.
  • Schulze J; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Mieth M; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Hellwig K; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Demir Z; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Biere B; Unit 17 "Influenza and other Respiratory Viruses", Robert Koch Institut, Berlin, Germany.
  • Brunotte L; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Mecate-Zambrano A; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Bushe J; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Dohmen M; Unit 17 "Influenza and other Respiratory Viruses", Robert Koch Institut, Berlin, Germany.
  • Hinze C; Institute of Virology, Westfaelische Wilhelms Universität, Münster, Germany.
  • Elezkurtaj S; Institute of Virology, Westfaelische Wilhelms Universität, Münster, Germany.
  • Tönnies M; Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
  • Bauer TT; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Eggeling S; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Tran HL; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Schneider P; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Neudecker J; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Rückert JC; HELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn, Berlin, Germany.
  • Schmidt-Ott KM; HELIOS Clinic Emil von Behring, Department of Pneumology and Department of Thoracic Surgery, Chest Hospital Heckeshorn, Berlin, Germany.
  • Busch J; Department of Thoracic Surgery, Vivantes Clinics Neukölln, Berlin, Germany.
  • Klauschen F; Department of Thoracic Surgery, Vivantes Clinics Neukölln, Berlin, Germany.
  • Horst D; Department for Thoracic Surgery, DRK Clinics, Berlin, Germany.
  • Radbruch H; Department of General, Visceral, Vascular and Thoracic Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Radke J; Department of General, Visceral, Vascular and Thoracic Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Heppner F; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
  • Corman VM; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Niemeyer D; Clinic for Urology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Müller MA; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Goffinet C; Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Mothes R; Institute for Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Pascual-Reguant A; Institute for Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Hauser AE; Institute for Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Beule D; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Landthaler M; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Ludwig S; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Suttorp N; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Witzenrath M; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Gruber AD; Deutsches Rheuma-Forschungszentrum (DRFZ), a Leibniz Institute, Berlin, Germany.
  • Drosten C; Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Eur Respir J ; 60(6)2022 12.
Article em En | MEDLINE | ID: mdl-35728978
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / COVID-19 Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Influenza Humana / COVID-19 Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article