Prognosis of patients with poorly differentiated gastric neuroendocrine neoplasms: a multi-center study in China.
Future Oncol
; 18(22): 2465-2473, 2022 Jul.
Article
em En
| MEDLINE
| ID: mdl-35730464
ABSTRACT
Background:
The incidence of poorly differentiated gastric neuroendocrine neoplasms (G-NENs) has been increasing during the past decades.Methods:
A total of 183 patients diagnosed with poorly differentiated G-NENs were enrolled from eight hospitals during 2010-2019 in China. All cases included have accepted abdominal surgery in tertiary hospitals.Result:
T3 (HR 2.66, p = 0.019), T4 (HR 3.62, p = 0.005), stage IV (HR 5.67, p < 0.001), vascular invasion (HR 1.59, p = 0.048) were independent risk factors for poor prognosis of poorly differentiated G-NENs. In stratified analysis, for patients with stage III tumors, those treated with chemotherapy had significantly longer survival than those accepting surgery alone.Conclusion:
T3/T4 stage, TNM stage IV and vascular invasion were independent negative prognostic factors for patients with poorly differentiated G-NENs. Patients with stage III tumors can benefit from chemotherapy. Highly selected patients with stage IV tumors may also benefit from surgery.
This study mainly describes a rare cancerous gastric tumor. Numerous people have been diagnosed with this disease during the past decades. Owing to the small number of patients diagnosed with this disease, the treatment method is still not clear. In our study, we found that the outcome of patients who were diagnosed at late stage was much poorer than those diagnosed at early stage. So, it is important for patients to get accurate diagnosis in time. For a part of patients accepting surgery, they may benefit from chemotherapy.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Tumores Neuroendócrinos
Tipo de estudo:
Diagnostic_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article