Galunisertib Exerts Antifibrotic Effects on TGF-ß-Induced Fibroproliferative Dermal Fibroblasts.

Peterson, Joshua M; Jay, Jayson W; Wang, Ye; Joglar, Alejandro A; Prasai, Anesh; Palackic, Alen; Wolf, Steven E; El Ayadi, Amina

Peterson, Joshua M; Jay, Jayson W; Wang, Ye; Joglar, Alejandro A; Prasai, Anesh; Palackic, Alen; Wolf, Steven E; El Ayadi, Amina.

Afiliação

Peterson JM; Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jay JW; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Wang Y; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Joglar AA; School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Prasai A; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Palackic A; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.
Wolf SE; Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, A-8036 Graz, Austria.
El Ayadi A; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555, USA.

Int J Mol Sci ; 23(12)2022 Jun 15.

Article em En | MEDLINE | ID: mdl-35743131

Assuntos

Cicatriz; Fator de Crescimento Transformador beta; Proliferação de Células; Células Cultivadas; Cicatriz/patologia; Fibroblastos/metabolismo; Fibrose; Humanos; Pirazóis/metabolismo; Pirazóis/farmacologia; Quinolinas; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

ALK5; TGF- ß inhibition; fibrosis; injury; myofibroblast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Cicatriz Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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