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Discovery of 7, 4'-dimethoxy-3-hydroxyflavone as a protease-activated receptor 4 antagonist with antithrombotic activity and less bleeding tendency in mice.
Lin, Ying-Ting; Li, Yu; Hsu, Hui-Ching; Tsai, Ju-Ying; Lee, Jia-Hau; Tai, Chi-Jung; Wu, Ming-Jung; Wu, Chin-Chung.
Afiliação
  • Lin YT; Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Li Y; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Hsu HC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Tsai JY; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Lee JH; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Tai CJ; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • Wu MJ; Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
  • Wu CC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electro
Biochem Pharmacol ; 202: 115152, 2022 08.
Article em En | MEDLINE | ID: mdl-35752281
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombose / Inibidores da Agregação Plaquetária Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombose / Inibidores da Agregação Plaquetária Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article