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Oxalate crystal-related acute renal injury caused by orlistat: A case report. / 奥利司他致草酸盐结晶相关急性肾损伤1例.
Cui, Xinyuan; Chen, Xiaojun; Li, Yifu; Fu, Xiao; Song, Pan'ai; Xiao, Li; Sun, Lin; Liu, Hong; Zhu, Xuejing; Yuan, Shuguang.
Afiliação
  • Cui X; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China. cxy1997032021@163.com.
  • Chen X; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China. chenxiaojun2064@csu.edu.cn.
  • Li Y; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Fu X; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Song P; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Xiao L; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Sun L; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Liu H; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China.
  • Zhu X; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China. zhuxuejing5225209@csu.edu.cn.
  • Yuan S; Department of Nephrology, Second Xiangya Hospital, Central South University; Institute of Nephrology, Central South University, Changsha 410011, China. shuguangy@csu.edu.cn.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 47(5): 583-587, 2022 May 28.
Article em En, Zh | MEDLINE | ID: mdl-35753728
ABSTRACT
We reported a case of oxalate crystal-related acute kidney injury caused by orlistat. The patient was admitted for nephrotic syndrome and acute kidney injury. The pathomorphological assessment of renal biopsy showed intratubular oxalate crystals. The patient reported that she had taken orlistat regularly to loss weight for more than a year. This patient had a habit of drinking vegetable soup and strong herbal tea daily. Orlistat, an intestinal lipase inhibitor, may cause secondary hyperoxaluria, that is, intestinal hyperoxaluria. Dietary habits could be a common precipitating factor for orlistat-relevant hyperoxaluria. It was comprehensively considered to be oxalate crystal-related acute renal injury, and the patient's renal function recovered gradually after drug withdrawal. Clinicians should pay attention to screening drug-related acute kidney injury including orlistat when observing patients with unexplained acute kidney injury, and renal biopsy should be performed if necessary. It is also important to warn people who take the orlistat for weight loss about the side effects of this drug so as to adjust the eating habits.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperoxalúria / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En / Zh Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hiperoxalúria / Injúria Renal Aguda Tipo de estudo: Diagnostic_studies Limite: Female / Humans Idioma: En / Zh Ano de publicação: 2022 Tipo de documento: Article